Chemomab

The Challenge

Fibrosis-related diseases are a significant unmet need that dramatically affect patients health and quality of life.

Damaged tissue repairs itself through a sequence of controlled inflammatory and fibrotic processes. However, uncontrolled healing processes can create a vicious cycle of inflammation and fibrosis – an excessive, sustained, chronic inflammatory response that activates fibroblasts, and replaces functional tissue with fibrous scar tissue.

CCL24 - a Key Player

Regulating CCL24 is key to halting fibrosis-related conditions

Chemomab discovered that the soluble chemokine CCL24 plays a key role in promoting inflammation and fibrosis via a dual pathway. CCL24 promotes both the recruitment of immune cells to the damaged tissue and supports its polarization to create a pro-fibrotic environment. In parallel, CCL24 directly activates tissue fibroblasts, enhances their transition into myofibroblasts and induces the uncontrolled production of extracellular matrix.

CM-101 Therapeutic Platform

Pioneering innovation to treat fibrosis-related diseases.

Chemomab’s lead compound, CM-101, currently tested in phase II clinical studies, is a first-in-class humanized monoclonal antibody designed to bind to and block CCL24 activity.

CM-101 interferes with the main pathologies that promote fibrosis and inflammation. It is highly effective in ameliorating fibrosis, as shown across multiple in vivo, in vitro and ex vivo studies, including experimental models of liver, skin and lung fibrosis. CM-101 is currently under clinical development for Primary Sclerosing Cholangitis , Systemic Sclerosis and Non-Alcoholic Steatohepatitis.