Chemomab Therapeutics is a clinical-stage biotech company discovering and developing innovative therapeutics for conditions that involve inflammation and fibrosis and have high unmet need.
Our Vision
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Innovation
Translating novel biological insights into transformative treatments
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Evidence Driven
Drug discovery and development built on a deep understanding of central fibro-inflammatory mediators and pathways
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Improving Lives
Committed to improve the quality of life of patients suffering from seriously debilitating and life-threatening diseases
Innovation & Discovery
Chemomab discovered the key role of the soluble protein CCL24 in promoting liver, skin and lung fibrosis as the driver of a fibro-inflammatory vicious cycle
The Challenge
Fibrosis-related diseases are a significant unmet need that dramatically affect patients' health and quality of life.
Damaged tissue repairs itself through a sequence of controlled inflammatory and fibrotic processes. However, uncontrolled healing processes can create a vicious cycle of inflammation and fibrosis – an excessive, sustained, chronic inflammatory response that activates fibroblasts, and replaces functional tissue with fibrous scar tissue.
CCL24 - a Key Player
Regulating CCL24 is key to halting fibrosis-related conditions
Chemomab discovered that the soluble protein CCL24 plays a key role in promoting inflammation and fibrosis via a dual pathway. CCL24 promotes both the recruitment of immune cells to the damaged tissue and supports its polarization to create a pro-fibrotic environment. In parallel, CCL24 directly activates tissue fibroblasts, enhances their transition into myofibroblasts and induces the uncontrolled production of extracellular matrix.
CM-101 Therapeutic Platform
Pioneering innovation to treat fibrosis-related diseases.
Chemomab’s lead compound, CM-101 is a first-in-class humanized monoclonal antibody designed to bind to and neutralize CCL24 activity.
CM-101 interferes with the main pathologies that promote fibrosis and inflammation. It is highly effective in ameliorating fibrosis, as shown across multiple in vivo, in vitro and ex vivo studies, including experimental models of liver, skin and lung fibrosis. Chemomab has reported positive topline data from the CM-101 Phase 2 SPRING trial in patients with primary sclerosing cholangitis (PSC), a rare, potentially lethal disease of the bile ducts. It also has demonstrated encouraging biomarker data in a Phase 2a liver fibrosis trial in patients with metabolic-associated steatohepatitis (MASH), as well as activity in multiple preclinical models of systemic sclerosis (SSc).
To learn more about how CM-101 may interrupt the fibro-inflammatory vicious cycle believed to drive disease progression in PSC, see our Mechanism of Action (MOA) video at MOA video
Product Pipeline
Indication
Candidate
Discovery
Preclinical
Phase 1
Phase 2
Pivotal
IV — Intravenous
SC — Subcutaneous
Recent News
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Oral Presentation at AASLD The Liver Meeting® 2024 Highlights Broad Clinical Activity of Chemomab’s CM-101 Across Multiple Biomarkers and Its Disease-Modifying Potential in Primary Sclerosing Cholangitis
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Chemomab Therapeutics Announces Third Quarter 2024 Financial Results and Provides Corporate Update
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Chemomab Therapeutics to Report Third Quarter 2024 Financial Results and Provide a Business Update
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Chemomab Therapeutics Announces Late-Breaking Oral Presentation of CM-101 Phase 2 Results in Primary Sclerosing Cholangitis at AASLD The Liver Meeting® 2024